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apalutamide will reduce the level or impact of ethinylestradiol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with medication that are CYP3A4 substrates may lead to lower publicity to those medications.three. You can Come to be PREGNANT Should